Talk to your doctor before taking this medicine If you

• are allergic to ALTANIB or any of the other ingredients of this medicine
• have or have ever had a liver, kidney or heart problem
• have or ever had or might now have a hepatitis B infection

• If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
• ALTANIB is not recommended during pregnancy unless clearly necessary as it may harm your baby
• Do not breast-feed during the treatment with ALTANIB

• ALTANIB is also a treatment for children and adolescents with CML
• Some children and adolescents taking ALTANIB may have slower than normal growth

• You may feel dizzy or drowsy or get blurred vision while taking this medicine. If this happens, do not drive or use any tools or machines until you are feeling well again

• rapid weight gain may cause your body to retain water
• signs of infection such as fever, severe chills, sore throat or mouth ulcers
• unexpected bleeding or bruising
• chest pain, irregular heart rhythm
• cough, having difficulty breathing or painful breathing
• feeling light-headed, dizzy or fainting
• nausea with loss of appetite, dark-colored urine, yellow skin or eyes
• rash, red skin with blisters on the lips, eyes, skin or mouth, peeling skin, fever, raised red or purple skin patches, itching, burning sensation, pustular eruption
• severe abdominal pain, blood in your vomit, stools or urine, black stools
• severely decreased urine output, feeling thirsty
• feeling sick with diarrhea and vomiting, abdominal pain or fever
• severe headache, weakness or paralysis of limbs or face, difficulty speaking, sudden loss of consciousness
• pale skin, feeling tired, breathlessness and having dark urine
• eye pain or deterioration in vision
• pain in your hips or difficulty walking
• numb or cold toes and fingers
• sudden swelling and redness of the skin
• difficulty hearing
• muscle weakness and spasms with an abnormal heart rhythm
• bruising
• stomach pain with feeling sick
• pelvic pain sometimes with nausea and vomiting, with unexpected vaginal bleeding, feeling dizzy or fainting due to low blood pressure

• headache or feeling tired
• feeling sick (nausea), being sick (vomiting), diarrhea or indigestion
• rash
• muscle cramps or joint, muscle or bone pain
• swelling such as round your ankles or puffy eyes
• weight gain
• anorexia, weight loss or a disturbed sense of taste
• feeling dizzy or weak
• difficulty in sleeping (insomnia)
• discharge from the eye with itching, redness and swelling (conjunctivitis), watery eyes or having blurred vision
• nose bleeds
• pain or swelling in your abdomen, flatulence, heartburn or constipation
• itching
• unusual hair loss or thinning
• numbness of the hands or feet
• mouth ulcers
• joint pain with swelling
• dry mouth, dry skin or dry eye
• decreased or increased skin sensitivity
• hot flushes, chills or night sweats

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• Keep this medicine out of the sight and reach of children
• Do not use this medicine after the expiry date
• Do not use any pack that is damaged or shows signs of tampering
• Store at room temperature (15-25C)