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What is DEFRIJET 500MG?
- DEFRIJET 500MG contains Deferasirox. It is an iron chelator which is a medicine used to remove the excess iron from the body (also called iron overload)
- It traps and removes excess iron which is then excreted mainly in the stools
CONSUMER MEDICINE INFORMATION
THERAPEUTIC USES
WARNING & PRECAUTIONS
INTERACTIONS
DIRECTIONS FOR USE
SIDE EFFECTS
MORE INFORMATION
Talk to your doctor before taking DEFRIJET 500MG, if you:
- have a kidney or liver problem
- have a cardiac problem due to iron overload
- notice a marked decrease in your urine output (sign of kidney problem)
- have a low level of platelets or white blood cells in your blood test
- have blurred vision
- have diarrhoea or vomiting
- If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
- DEFRIJET 500MG is not recommended during pregnancy unless clearly necessary. Breast-feeding is not recommended during treatment with DEFRIJET 500MG
Tell your doctor if you are taking, have recently taken or might take any other medicines.
This includes in particular:
- other iron chelators, which must not be taken with DEFRIJET 500MG
- antacids (medicines used to treat heartburn) containing aluminium
- ciclosporin (used to prevent the body rejecting a transplanted organ or for other conditions, such as rheumatoid arthritis or atopic dermatitis)
- simvastatin (used to lower cholesterol)
- certain painkillers or anti-inflammatory medicines (e.g. aspirin, ibuprofen, corticosteroids)
- oral bisphosphonates (used to treat osteoporosis)
- anticoagulant medicines (used to prevent or treat blood clotting)
- hormonal contraceptive agents (birth control medicines)
- bepridil, ergotamine (used for heart problems and migraines)
- repaglinide (used to treat diabetes)
- rifampicin (used to treat tuberculosis)
- phenytoin, phenobarbital, carbamazepine (used to treat epilepsy)
- ritonavir (used in the treatment of HIV infection)
- paclitaxel (used in cancer treatment)
- theophylline (used to treat respiratory diseases such as asthma)
- clozapine (used to treat psychiatric disorders such as schizophrenia)
- tizanidine (used as a muscle relaxant)
- cholestyramine (used to lower cholesterol levels in the blood)
- Always take this medicine exactly as your doctor has told you
- Take DEFRIJET 500MG once a day, every day, at about the same time each day with some water
- Take DEFRIJET 500MG tablets either on an empty stomach or with a light meal
- The dose of DEFRIJET 500MG is related to body weight for all patients. Your doctor will calculate the dose you need and tell you how many tablets to take each day
- The usual daily dose for DEFRIJET 500MG film-coated tablets at the start of the treatment for patients receiving regular blood transfusions is 14 mg per kilogram body weight. A higher or lower starting dose may be recommended by your doctor based on your individual treatment needs
- This is a long-term treatment, possibly lasting for months or years. Your doctor will regularly monitor your condition to check that the treatment is having the desired effect
If you take more DEFRIJET 500MG
- If you have taken too much DEFRIJET 500MG, or if someone else accidentally takes your tablets, contact your doctor or hospital for advice straight away
If you forget to take DEFRIJET 500MG
- If you miss a dose, take it as soon as you remember on that day. Take your next dose as scheduled
- Do not take a double dose on the next day to make up for the forgotten tablet(s)
If you stop taking DEFRIJET 500MG
- Do not stop taking DEFRIJET 500MG unless your doctor tells you to. If you stop taking it, the excess iron will no longer be removed from your body
Like all medicines, this medicine can cause side effects, although not everybody gets them.
SERIOUS
COMMON
UNCOMMON
RARE
VERY RARE
- get blurred or cloudy eyesight
- get reduced hearing
- difficulty breathing and dizziness or swelling mainly of the face and throat.
- rash, red skin, blistering of the lips, eyes or mouth, skin peeling, high fever, flu-like symptoms, enlarged lymph nodes
- a combination of drowsiness, upper right abdominal pain, yellowing or increased yellowing of your skin or eyes and dark urine (signs of liver problems)
- vomit blood and/or have black stools
- partial loss of vision
- severe upper stomach pain (pancreatitis)
- disturbance in kidney function tests
- gastrointestinal disorders, such as nausea, vomiting, diarrhoea, pain in the abdomen, bloating, constipation, indigestion
- headache
- disturbance in liver function tests
- itching
- disturbance in urine test (protein in the urine)
