Tell your doctor before taking this medicine, if you:

• are allergic (hypersensitive) to tacrolimus or any of the other ingredients of TAKFA 1MG
• are allergic to any macrolide-antibiotic (e.g. erythromycin, clarithromycin, josamycin)
• have or have had liver problems
• have diarrhoea for more than one day
• feel strong abdominal pain accompanied or not with other symptoms, such as chills, fever, nausea or vomiting
• have an alteration of the electrical activity of your heart called QT prolongation

• If you are, think you might be or are planning to become pregnant or breast feeding, ask your doctor for advice before using TAKFA 1MG

• The use of TAKFA 1MG is not recommended in children and adolescents under 18 years of age

• Do not drive or use any tools or machines if you feel dizzy or sleepy, or have problems seeing clearly after taking TAKFA 1MG

• allergic and anaphylactic reactions
• benign and malignant tumours
• cases of pure red cell aplasia, agranulocytosis and haemolytic anaemia

• reduction in blood cell counts, increase in white blood cell counts, changes in red blood cell counts (seen in blood tests).
• decreased appetite, increased acidity of the blood
• anxiety symptoms, confusion and disorientation, depression, mood changes, nightmare, hallucination, mental disorders
• fits, disturbances in consciousness, tingling and numbness (sometimes painful) in the hands and feet, dizziness, impaired writing ability, nervous system disorders
• blurred vision, increased sensitivity to light, eye disorders, ringing sound in your ears
• reduced blood flow in the heart vessels, faster heartbeat
• bleeding, partial or complete blocking of blood vessels, reduced blood pressure
• shortness in breath, disorders of the respiratory tissues in the lung, collection of liquid around the lung, inflammation of the pharynx, cough
• abdominal pain, bleeding in the stomach, inflammation or ulcer in the mouth, collection of fluid in the belly, vomiting, indigestion, constipation, passing wind, bloating
• yellowing of the skin due to liver problems
• itching, rash, hair loss, acne, increased sweating
• pain in joints, limbs or back, muscle spasms
• insufficient function of the kidneys, reduced production of urine, impaired or painful urination
• general weakness, fever, collection of fluid in your body, pain and discomfort, weight gain
• insufficient function of your transplanted organ
• increased blood sugar, diabetes mellitus, increased potassium in the blood
• difficulty in sleeping, trembling, headache, increased blood pressure
• diarrhoea, nausea

• changes in blood clotting, reduction in the number of all types of blood cells (seen in blood tests)
• dehydration, inability to urinate

• small bleedings in your skin due to blood clots
• increased muscle stiffness
• blindness, deafness
• collection of fluid around the heart
• cyst formation in your pancreas
• problems with blood flow in the liver
• serious illness with blistering of skin, mouth, eyes and genitals; increased hairiness
• thirst, fall, feeling of tightness in your chest, decreased mobility, ulcer

• muscular weakness
• abnormal heart scan
• painful urination with blood in the urine
• increase of fat tissue

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• Keep out of reach of children
• Do not use TAKFA 1MG after the expiry date
• Store at room temperature (15 to 25C)