Login
0
₹ 0
What is ZIGMA CR 400MG?
- ZIGMA CR 400MG contains Carbamazepine which belongs to a group of medicines called antiepileptics
CONSUMER MEDICINE INFORMATION
THERAPEUTIC USES
WARNING & PRECAUTIONS
INTERACTIONS
DIRECTIONS FOR USE
SIDE EFFECTS
MORE INFORMATION
Talk your doctor before taking this medicine, if you:
- are allergic to Carbamazepine or any of the ingredients of this medicine
- are allergic to similar drugs such as oxcarbazepine or phenytoin or a tricyclic antidepressant (e.g. amitriptyline)
- have a heart condition or had a problem with your bone marrow
- or a member of your family has the rare blood pigment disorder called porphyria
- have a history of liver or kidney disease
- have glaucoma (increased pressure in the eye)
- have a difficulty to retain your urine
- have suffered from a mental illness in the past
- are elderly
- suffer from epilepsy from the sort of epilepsy where you get mixed seizures
- have blood disorders
- consume alcohol
Tell your doctor if you are taking, have recently taken or might take any of the following medicines:
- other antiepileptics e.g. lamotrigine, phenytoin, fosphenytoin, primidone, sodium valproate, phenobarbitone, ethosuximide, oxcarbazepine, tiagabine, topiramate, vigabatrin, levetiracetam, progabide
- anticoagulants to thin the blood e.g. warfarin, acenocoumarol
- cimetidine or omeprazole, to treat heartburn or stomach ulcers
- medicine to treat mental illness e.g. lithium, haloperidol, thioridazine, olanzapine, risperidone, imipramine, fluoxetine, amitriptyline
- paliperidone or aripiprazole, to treat schizophrenia
- sedatives e.g. clobazam, clonazepam, alprazolam, valnoctamide
- metoclopramide or aprepitant, often used to treat motion sickness
- antibiotics e.g. doxycycline, isoniazid, erythromycin, clarithromycin, ciprofloxacin
- isoniazid, rifampicin (used to treat tuberculosis)
- antifungals e.g. itraconazole, fluconazole, ketoconazole, voriconazole, albendazole
- corticosteroids e.g. prednisolone, dexamethasone
- ciclosporin, tacrolimus or sirolimus, immunosuppressants
- painkillers containing paracetamol, dextropropoxyphene, methadone, tramadol, buprenorphine
- medicine to treat heart conditions e.g. felodipine, isradipine, digoxin, verapamil, diltiazem
- diuretics e.g. furosemide, hydrochlorothiazide
- acetazolamide, to treat glaucoma
- muscle relaxants, often used during operations e.g. pancuronium
- isotretinoin, used to treat acne
- theophylline and aminophylline, for asthma
- danazol and gestrinone (used in the treatment of endometriosis)
- hormonal contraceptives e.g. pills, patches, injections or implants
- tibolone, used as hormone Replacement Therapy (HRT)
- tadalafil, used to treat impotence
- drugs to treat cancer e.g. imatinib, lapatinib, toremifene, cisplatin, doxorubicin, temsirolimus, cyclophosphamide
- mefloquine, used to treat malaria
- drugs to treat HIV known as protease inhibitors (e.g. indinavir, ritonavir, saquinavir)
- levothyroxine to treat hypothyroidism
- antihistamines to treat allergies and hayfever, such as loratadine
- medicine or supplements containing Vitamin B (nicotinamide)
- Always take this medicine exactly as your doctor has told you
- Your doctor is likely to start treatment with a low dose and slowly increase it to suit your own needs
- Swallow the tablet whole, with a glass of water
- Do not chew, crush or suck the tablet
Recommended doses are as follows:
Adults:
- The recommended starting dose is 100 mg to 200 mg of ZIGMA CR 400MG once or twice daily
- Your doctor will slowly increase this dose to control your fits until the best response is obtained, often 800 to 1200 mg daily in divided doses, although higher doses may be necessary
Use in children and adolescents:
- The recommended daily dose for children between 5 and 10 years old is 400 mg to 600 mg of ZIGMA CR 400MG, divided up throughout the day
- Children over 10 years old may be given a total daily dose of between 600 mg and 1000 mg of ZIGMA CR 400MG, divided up throughout the day
Trigeminal Neuralgia
- The starting dose is 200 to 400 mg daily (100 mg twice daily in elderly patients)
- Your doctor may increase the dose until you are free from pain
Treatment of Mood Swings
- The starting dose is 400 mg of ZIGMA CR 400MG daily, divided up throughout the day. This dose may be increased slowly until your symptoms are controlled or until the maximum daily dose of 1600 mg of ZIGMA CR 400MG is reached. The usual daily dose range is 400 600 mg in divided doses
If you take more ZIGMA CR 400MG
- If you take more ZIGMA CR 400MG than you should, contact your doctor or local hospital emergency department immediately
If you forget to take a dose
- If you forget to take a dose take it as soon as you remember unless it is nearly time for your next dose.
- Do not take double dose to make up for a forgotten dose
If you stop taking ZIGMA CR 400MG
- If you stop taking ZIGMA CR 400MG suddenly you may suffer unpleasant side effects. Always ask your doctor first before stopping the treatment
Like all medicines, this medicine can cause side effects, although not everybody gets them.
SERIOUS
COMMON
UNCOMMON
RARE
VERY RARE
- a low white cell count (leucopenia) causing more infections than usual
- severe peeling of the skin which can affect a large area of your body
- have difficulty in breathing, experience chest pain, wheezing and coughing, a rash, itching, facial swelling or feel faint, all symptoms of a severe allergic reaction
- suffer from pain in your joints and muscles
- notice any unusual signs of mental illness or confusion
- suffer from a sore throat, high temperature or both
- a sudden increase in body temperature, extremely high blood pressure and severe convulsions (neuroleptic malignant syndrome)
- have severe or persistent pain in the stomach region that spreads to the lower back, often with nausea and vomiting (pancreatitis)
- meningitis (signs and symptoms include fever, headache, stiff neck, extreme sensitivity to sunlight, twitching of muscles, abnormal blood test results)
- unexplained bruising or bleeding of your skin which could show you have anemia (a change in your blood)
- blood clot (thrombosis), which can cause tenderness, swelling, pain chest, shortness of breath; shortness of breath, swelling of feet or legs due to fluid build-up, getting tired easily after light physical activity
- yellowing of your skin or the white of your eyes, dark urine, light coloured bowel motions, nausea, vomiting, and feeling generally unwell
- severe allergic reactions (signs include wheezing, coughing, difficulty in breathing, feeling faint, rash, itching, swelling of the face, lips, mouth, tongue or throat)
- feeling dizzy, tired or drowsy
- difficulty controlling movements and feeling unsteady
- skin reactions, including hives (urticaria) which may be severe
- Changes in liver enzyme levels (usually without any symptoms)
- swollen ankles or lower legs, fluid retention weight gain
- low sodium levels in the blood causing headache, confusion, being sick, lethargy, muscular twitching, convulsions
- double vision, eyesight changes e.g. blurred vision
- dry mouth
- headache
- changes in the blood including an increased tendency to bruise or bleed
- eosinophilia (increase in some white blood cells)
- increase in alkaline phosphatase (an enzyme found in body tissues such as liver and bone)
- abnormal movements or uncontrollable muscle spasms involving the arms, legs, eye, head, neck and other parts of the body
- shaking (tremor)
- diarrhoea or constipation
- Increased levels of certain enzymes in the body (seen in a blood test)
- folic acid deficiency
- increased levels of white blood cells in the body (seen in a blood test)
- fever
- disease of the lymph glands
- hallucinations (seeing or hearing things that are not there)
- depression or mood changes
